It may also help to clear your console cache (found under "memory > device options") which will then prompt you to re-download any patches issued on XBL when you next launch the game. If you are experiencing game freezing and frame rate drops, loading screens that last 60 seconds and longer, or multiple crashes ensuing from the same action or location, installing the game can help with some of these issues.
(For Xbox 360 users removing the auto-save function, in the settings menu will remove most of the save time/corruption issues ) A frequently overwritten autosave slot can easily become corrupted.
2 Patch 1.1.1.271 "Everything's Essential" bug.